Abstract
Objective: To investigate the role of angiotensin receptors(ATRs) in pressure overload-induced left ventricular hypertrophy (LVH).
Methods: The model of rat abdominal aortic constriction was adapted. At 10th week after operating, Ang II in myocardium was measured by radioimmunoassay, tissue ATRs and its subtype were analysed by radioligand binding assay.
Results: The content of Ang II in the operated group was significantly more than that in the control group. Left ventricular mass index (LVMI) was positively correlated with Ang II (r=0.8066, P
Conclusions: These results suggest that left ventricular ATRs were upregulated during the pressure overload. The left ventricular hypertrophy induced by Ang II is mainly due to AT1 R pathway.
Recommended Citation
Ping Zhang, Guoxiang He, Luxiang Chi, Role of Angiotensin II Receptors in Pressure Overload-induced Left Ventricular Hypertrophy Journal of the Hong Kong College of Cardiology 2001;9(2) https://doi.org/10.55503/2790-6744.1162
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