Thrombolytic Therapy for Acute Myocardial Infarction in the Elderly
Acute myocardial infarction (MI) is a leading cause of morbidity and mortality in developed countries. Patients ≥75 years constitute up to 30% of the acute MI population and are associated with a 50% in-hospital mortality. Thrombolytic therapy was shown in a metaanalysis of 9 largest randomized controlled trials to reduce 35-day mortality. However, the benefit was observed mainly among patients < 75 years old. For patients ≥ 75 years, the 35-day mortality was 24.3% in those treated with thrombolytic therapy and 25.3% in the placebo group, a difference not reaching statistical significance.
Bernard Bun-Lap Wong, Wai-Hong Chen, Thrombolytic Therapy for Acute Myocardial Infarction in the Elderly Journal of the Hong Kong College of Cardiology 2001;9(2) https://doi.org/10.55503/2790-6744.1161