Ivabradine is a specific funny current inhibitor, which blocks Hyperpolarization-activated Cyclic Nucleotide-gated cation channels intra-cellularly and results in delayed diastolic depolarization in a use-dependent manner. Prior-believed to be exclusively expressed within the sinoatrial node, funny channels were recently revealed to be also expressed in the atrioventricular node and throughout the myocardium. These invite a key clinical question as whether pharmacological effects of ivabradine may extend beyond its conventional clinical use.
Here reported is an unusual case of atrioventricular dissociation associated with ivabradine use, dissecting which may lead us to consider broader potential implications of this observation
Yap-Hang Will Chan, Unusual Manifestation of Atrioventricular Dissociation in A 63 Year-Old Man and Clinical Insights Journal of the Hong Kong College of Cardiology ;30(5) https://doi.org/10.55503/2790-6744.1515
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.